Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6854445 | 0.84 | SLC6A2 (0.35) | ELANEMAPK8MMP2MMP9MMP8 | |
| SCHEMBL6854433 | 0.82 | PIK3R1 (0.36) | SMN1; SMN2 | |
| SCHEMBL6850159 | 0.74 | SLC6A2 (0.35) | L3MBTL1MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL6856311 | 0.72 | SMN1; SMN2 (0.33) | SMN1; SMN2 | |
| SCHEMBL6850047 | 0.67 | HPGD (0.32) | MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL6854036 | 0.65 | SMN1; SMN2 (0.43) | MAPTALDH1A1FGFR1SMN1; SMN2NPC1 | |
| SCHEMBL6854989 | 0.64 | PIK3R1 (0.33) | USP2 | |
| SCHEMBL6850174 | 0.64 | MAPK8 (0.51) | MAPK8MAPK10MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL28480224 | 0.62 | ELANE (0.48) | ELANEMAPK8MMP2MMP9MMP8 | |
| SCHEMBL7623 | 0.59 | CA1 (0.64) | L3MBTL1MAPTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828315-B1 | Anti- inflammatories, anti-allergics, bronchodilatators, anti-asthmatics, or TNF alpha inhibitors | WARNER-LAMBERT LLC | 2004-12-07 | — | — | US | claimed |
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | claimed |
| JP-2002543199-A | — | — | 2002-12-17 | — | — | JP | claimed |
| EP-1177195-A1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER-LAMBERT COMPANY (US) | 2002-02-06 | — | — | EP | claimed |
| WO-2000066584-B1 | 1-AMINO TRIAZOLO¢4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2001-02-15 | — | — | WO | claimed |
| WO-2000066584-A1 | 1-AMINO TRIAZOLO¢4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER-LAMBERT COMPANY (US) | 2000-11-09 | — | — | WO | claimed |
| US-6828315-B1 | Anti- inflammatories, anti-allergics, bronchodilatators, anti-asthmatics, or TNF alpha inhibitors | WARNER-LAMBERT LLC | 2004-12-07 | — | — | US | disclosed |
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | disclosed |
| US-20020119967-A1 | Pharmaceutical composition for preventing or treating a disease associated with an excess of IL-12-production | WARNER-LAMBERT COMPANY | 2002-08-29 | — | — | US | disclosed |
| WO-2002022112-A9 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING A DISEASE ASSOCIATED WITH AN EXCESS OF IL-12 PRODUCTION | WARNER LAMBERT CO (US) | 2002-06-06 | — | — | WO | disclosed |
| EP-1199074-A1 | Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production | WARNER-LAMBERT COMPANY (US) | 2002-04-24 | — | — | EP | disclosed |
| EP-1188438-A1 | Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production | WARNER-LAMBERT COMPANY (US) | 2002-03-20 | — | — | EP | disclosed |