Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6849534 | 0.84 | CHRNA7 (0.38) | CHRNA7USP30 | |
| SCHEMBL6845650 | 0.81 | CHRNA7 (0.42) | CHRNA7USP30HRH3JAK2JAK1 | |
| SCHEMBL6849715 | 0.79 | CHRM1 (0.48) | CHRNA7JAK2JAK1 | |
| SCHEMBL6412566 | 0.74 | CHRNA7 (0.62) | CHRNA7 | |
| SCHEMBL6412568 | 0.74 | CHRNA7 (0.62) | CHRNA7 | |
| SCHEMBL6417949 | 0.74 | CHRNA7 (0.62) | CHRNA7 | |
| SCHEMBL6851401 | 0.69 | — | — | |
| SCHEMBL6849998 | 0.69 | CHRNA7 (0.42) | CHRNA7 | |
| SCHEMBL6849878 | 0.69 | CHRNA7 (0.40) | CHRNA7USP30 | |
| SCHEMBL6848649 | 0.69 | CHRNA7 (0.42) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476449-A1 | FUSED BICYCLIC-N-BRIDGED-HETEROAROMATIC CARBOXAMIDES FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-11-17 | — | — | EP | claimed |
| WO-2003070732-A1 | FUSED BICYCLIC-N-BRIDGED-HETEROAROMATIC CARBOXAMIDES FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2003-08-28 | — | — | WO | claimed |