SCHEMBL6845650

SCHEMBL6845650

CN(C(=O)c1ccc2cccn2c1)C1CN2CC[C@H]1C2

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 7/20 0.42
CHRM2 P08172 2/20 0.42
CHRM1 P11229 2/20 0.42
CHRM3 P20309 2/20 0.42
ALDH1A1 P00352 1/20 0.34
SIGMAR1 Q99720 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
TSHR P16473 1/20 0.34
CYP2C19 P33261 1/20 0.34
JAK2 O60674 1/20 0.34
JAK1 P23458 1/20 0.34
USP30 Q70CQ3 1/20 0.33
CHRM5 P08912 1/20 0.33
HRH3 Q9Y5N1 3/20 0.33
PDK2 Q15119 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6849715 0.94 CHRM1 (0.48) CHRNA7CHRM2CHRM1CHRM3ALDH1A1
SCHEMBL6845640 0.84 CHRNA7 (0.42) CHRNA7CHRM2CHRM1CHRM3SIGMAR1
SCHEMBL6849878 0.83 CHRNA7 (0.40) CHRNA7CHRM2CHRM1CHRM3USP30
SCHEMBL6848612 0.83 CHRNA7 (0.40) CHRNA7CHRM2CHRM1CHRM3ALDH1A1
SCHEMBL6850187 0.81 CHRNA7 (0.39) CHRNA7JAK2JAK1USP30HRH3
SCHEMBL6849713 0.77 CHRNA7 (0.43) CHRNA7CHRM2CHRM1CHRM3ALDH1A1
SCHEMBL6848954 0.77 CHRNA7 (0.43) CHRNA7CHRM2CHRM1CHRM3ALDH1A1
SCHEMBL6851401 0.74
SCHEMBL6411769 0.74 CHRNA7 (0.67) CHRNA7TSHR
SCHEMBL16884558 0.71 CHRNA7 (0.52) CHRNA7CHRM2CHRM1CHRM3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1476449-A1 FUSED BICYCLIC-N-BRIDGED-HETEROAROMATIC CARBOXAMIDES FOR THE TREATMENT OF DISEASE PHARMACIA & UPJOHN COMPANY (US) 2004-11-17 EP disclosed
WO-2003070732-A1 FUSED BICYCLIC-N-BRIDGED-HETEROAROMATIC CARBOXAMIDES FOR THE TREATMENT OF DISEASE PHARMACIA & UPJOHN COMPANY (US) 2003-08-28 WO disclosed