⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19314571 | 0.94 | — | — | |
| SCHEMBL6850234 | 0.86 | — | — | |
| SCHEMBL6850232 | 0.64 | — | — | |
| SCHEMBL4554901 | 0.63 | KDM4E (0.36) | — | |
| SCHEMBL7413678 | 0.63 | ALDH1A1 (0.33) | — | |
| SCHEMBL31757225 | 0.62 | — | — | |
| SCHEMBL19674910 | 0.61 | — | — | |
| Hydrochloric Acid SCHEMBL20262983 | 0.61 | KDM4E (0.35) | — | |
| SCHEMBL11344971 | 0.61 | KDM4E (0.41) | — | |
| SCHEMBL5429782 | 0.60 | KDM4E (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114478516-A | 3, 4-dihydro-2H-quinolizin-2-ketone compound and preparation method thereof | 中国科学院成都有机化学有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-114478516-A | 3, 4-dihydro-2H-quinolizin-2-ketone compound and preparation method thereof | 中国科学院成都有机化学有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-107074958-A | Anti- PD L1 for treating tumour are combined | 博笛生物科技有限公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-107074959-A | Anti- PD L1 conjugates for treating tumour | 博笛生物科技有限公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-106943596-A | anti-CD 20 combination for use in the treatment of tumors | 博笛生物科技（北京）有限公司 | 2017-07-14 | — | — | CN | disclosed |
| CN-106943598-A | anti-HER 2 combination for treating tumors | 博笛生物科技（北京）有限公司 | 2017-07-14 | — | — | CN | disclosed |
| CN-106943597-A | Anti-EGFR Combinations for the Treatment of Tumors | 博笛生物科技（北京）有限公司 | 2017-07-14 | — | — | CN | disclosed |
| WO-2011036885-A1 | HETEROCYCLIC COMPOUND | 武田薬品工業株式会社 (JP) | 2011-03-31 | — | — | WO | disclosed |