Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 20/20 | 0.54 |
| ▸ | PTPN2 | P17706 | 5/20 | 0.49 |
| ▸ | PTPRC | P08575 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7165567 | 0.92 | PTPN1 (0.66) | PTPN1PTPN2PTPRC | |
| SCHEMBL7165297 | 0.91 | PTPN1 (0.54) | PTPN1PTPN2PTPRC | |
| SCHEMBL6850495 | 0.88 | PTPN1 (0.68) | PTPN1PTPN2PTPRC | |
| SCHEMBL7165292 | 0.86 | PTPN1 (0.69) | PTPN1PTPN2PTPRC | |
| SCHEMBL7169128 | 0.84 | PTPN1 (0.44) | PTPN1PTPN2PTPRC | |
| SCHEMBL7165563 | 0.84 | PTPN1 (0.77) | PTPN1PTPN2PTPRC | |
| SCHEMBL7166899 | 0.82 | PTPN1 (0.60) | PTPN1PTPN2PTPRC | |
| SCHEMBL7164058 | 0.81 | PTPN1 (0.39) | PTPN1PTPN2PTPRC | |
| SCHEMBL6850740 | 0.79 | PTPN1 (0.54) | PTPN1PTPN2PTPRC | |
| SCHEMBL7659262 | 0.79 | PTPN1 (0.55) | PTPN1PTPN2PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242431-A1 | AROMATIC PHOSPHONATES AS PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) INHIBITORS | Merck Frosst Canada & Co. (CA) | 2002-09-25 | — | — | EP | claimed |
| US-6448429-B1 | TREATING OR PREVENTING PTP-1B MEDIATED DISEASES, INCLUDING DIABETES, OBESITY, AND DIABETES-RELATED CONDITIONS. | MERCK FROSST CANADA & CO. (CA) | 2002-09-10 | — | — | US | claimed |
| US-20020052347-A1 | Protein tyrosine phosphatase 1B (PTP-1B) inhibitors containing two ortho-substituted aromatic phosphonates | MERCK FROSST CANADA LTD. (CA) | 2002-05-02 | — | — | US | claimed |
| WO-2001046204-A1 | AROMATIC PHOSPHONATES AS PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2001-06-28 | — | — | WO | claimed |
| US-6777433-B2 | BIS((DIFLUORO-PHOSPHONATO-METHYL)PHENYL) DERIVATIVES; ANTIDIABETIC AND ANTIOBESITY AGENTS | MERCK FROSST CANADA & CO. (CA) | 2004-08-17 | — | — | US | disclosed |
| US-20030114703-A1 | Protein tyrosine phosphatase 1B (PTP-1B) inhibitors containing two ortho-substituted aromatic phosphonates | MERCK FROSST CANADA LTD. (CA) | 2003-06-19 | — | — | US | disclosed |
| EP-1242431-A1 | AROMATIC PHOSPHONATES AS PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) INHIBITORS | Merck Frosst Canada & Co. (CA) | 2002-09-25 | — | — | EP | disclosed |
| US-6448429-B1 | TREATING OR PREVENTING PTP-1B MEDIATED DISEASES, INCLUDING DIABETES, OBESITY, AND DIABETES-RELATED CONDITIONS. | MERCK FROSST CANADA & CO. (CA) | 2002-09-10 | — | — | US | disclosed |
| US-20020052347-A1 | Protein tyrosine phosphatase 1B (PTP-1B) inhibitors containing two ortho-substituted aromatic phosphonates | MERCK FROSST CANADA LTD. (CA) | 2002-05-02 | — | — | US | disclosed |
| WO-2001046204-A1 | AROMATIC PHOSPHONATES AS PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2001-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114703-A1 | Protein tyrosine phosphatase 1B (PTP-1B) inhibitors containing two ortho-substituted aromatic phosphonates | PTPRO, PTPN1, PTPRS | PTPN1 2/4885PTPN2 22/4885PTPRC 8/4885 |
| US-20020052347-A1 | Protein tyrosine phosphatase 1B (PTP-1B) inhibitors containing two ortho-substituted aromatic phosphonates | PTPRO, PTPN1, PTPRS | PTPN1 2/4885PTPN2 22/4885PTPRC 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.