Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.60 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | TDP2 | O95551 | 2/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | CASP9 | P55211 | 1/20 | 0.54 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MGAM | O43451 | 1/20 | 0.52 |
| ▸ | SI | P14410 | 1/20 | 0.52 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6850832 | 1.00 | IGF1R (0.61) | IGF1RMEN1KMT2ACASP3BLM | |
| SCHEMBL4333700 | 0.78 | PIK3CA (0.63) | IGF1RMEN1KMT2ATDP2CASP7 | |
| SCHEMBL4333702 | 0.78 | PIK3CA (0.63) | IGF1RMEN1KMT2ATDP2CASP7 | |
| SCHEMBL1250598 | 0.76 | IGF1R (1.00) | IGF1RMEN1KMT2ACASP3BLM | |
| SCHEMBL13846818 | 0.76 | IGF1R (1.00) | IGF1RMEN1KMT2ACASP3BLM | |
| SCHEMBL1250596 | 0.76 | IGF1R (1.00) | IGF1RMEN1KMT2ACASP3BLM | |
| SCHEMBL5734991 | 0.76 | ERN1 (0.54) | MEN1KMT2ATDP2GAAALDH1A1 | |
| SCHEMBL5146476 | 0.75 | MEN1 (1.00) | IGF1RMEN1KMT2ACASP3BLM | |
| SCHEMBL5146470 | 0.75 | MEN1 (1.00) | IGF1RMEN1KMT2ACASP3BLM | |
| SCHEMBL3938888 | 0.71 | TDP2 (1.00) | IGF1RMEN1KMT2ATDP2CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294378-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2004-01-28 | — | — | EP | disclosed |
| EP-1294378-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001089457-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-29 | — | — | WO | disclosed |