Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6850984 | 1.00 | MKNK1 (0.56) | MKNK1MKNK2CYP2A6ALDH1A1CYP1A2 | |
| SCHEMBL6854146 | 0.81 | ATM (0.42) | MKNK1MKNK2CYP2A6ERN1 | |
| SCHEMBL6854141 | 0.81 | ATM (0.42) | MKNK1MKNK2CYP2A6ERN1 | |
| SCHEMBL6877224 | 0.81 | MKNK1 (0.54) | MKNK1MKNK2CYP2A6ALDH1A1CYP1A2 | |
| SCHEMBL6877229 | 0.81 | MKNK1 (0.54) | MKNK1MKNK2CYP2A6ALDH1A1CYP1A2 | |
| SCHEMBL6877227 | 0.81 | MKNK1 (0.54) | MKNK1MKNK2CYP2A6ALDH1A1CYP1A2 | |
| SCHEMBL6851938 | 0.80 | HDAC1 (0.44) | MKNK2CYP3A4KIF11CYP11B2LMNA | |
| SCHEMBL6851935 | 0.80 | HDAC1 (0.44) | MKNK2CYP3A4KIF11CYP11B2LMNA | |
| SCHEMBL28753666 | 0.77 | DYRK1A (0.54) | MKNK1MKNK2CYP2A6ALDH1A1CYP1A2 | |
| SCHEMBL8228555 | 0.76 | MKNK1 (0.64) | MKNK1MKNK2CYP2A6ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |