Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 2/20 | 0.42 |
| ▸ | QDPR | P09417 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.36 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.36 |
| ▸ | AKT1 | P31749 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.36 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.36 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6851938 | 1.00 | HDAC1 (0.44) | HDAC1HDAC6MAPTLMNAKIF11 | |
| SCHEMBL6854146 | 0.81 | ATM (0.42) | HDAC1ERN1MKNK2 | |
| SCHEMBL6854141 | 0.81 | ATM (0.42) | HDAC1ERN1MKNK2 | |
| SCHEMBL6850984 | 0.80 | MKNK1 (0.56) | MAPTLMNAKIF11ERN1SMN1; SMN2 | |
| SCHEMBL6850990 | 0.80 | MKNK1 (0.56) | MAPTLMNAKIF11ERN1SMN1; SMN2 | |
| SCHEMBL6852059 | 0.79 | CYP2D6 (0.42) | MAPTGSK3BPRKCDROCK1PRKG1 | |
| SCHEMBL6852058 | 0.79 | CYP2D6 (0.42) | MAPTGSK3BPRKCDROCK1PRKG1 | |
| SCHEMBL6852193 | 0.78 | CLK4 (0.41) | CLK4DYRK1ACYP3A4MKNK2 | |
| SCHEMBL6852195 | 0.78 | CLK4 (0.41) | CLK4DYRK1ACYP3A4MKNK2 | |
| SCHEMBL6879912 | 0.77 | HDAC1 (0.42) | HDAC1HDAC6MAPTLMNAKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1585775-A | 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials | ORTHO MCNEIL PHARM INC (US) | 2005-02-23 | — | — | CN | disclosed |
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |