Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 15/20 | 0.67 |
| ▸ | TACR2 | P21452 | 10/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | DHODH | Q02127 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6848956 | 0.88 | TACR2 (0.61) | TACR3TACR2OPRM1KCNH2PDE10A | |
| SCHEMBL6851678 | 0.88 | TACR3 (0.69) | TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6853618 | 0.87 | TACR2 (0.55) | TACR3TACR2OPRM1KCNH2PDE10A | |
| SCHEMBL6853012 | 0.87 | TACR3 (0.64) | TACR3TACR2OPRM1KCNH2PDE10A | |
| SCHEMBL5452655 | 0.86 | TACR2 (0.54) | TACR3TACR2OPRM1KCNH2PDE10A | |
| SCHEMBL6855404 | 0.86 | TACR2 (0.54) | TACR3TACR2OPRM1KCNH2PDE10A | |
| SCHEMBL6266946 | 0.86 | TACR2 (0.59) | TACR3TACR2OPRM1KCNH2PDE10A | |
| SCHEMBL6853307 | 0.86 | TACR3 (0.54) | TACR3TACR2OPRM1KCNH2PDE10A | |
| SCHEMBL5455845 | 0.86 | TACR2 (0.56) | TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6852983 | 0.86 | TACR2 (0.56) | TACR3TACR2OPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | claimed |
| CN-1407850-A | Process for converting storage reserves of dicot seeds into compositions comprising one or more gene products | UNICROP LTD (FI) | 2003-04-02 | — | — | CN | disclosed |
| CN-1406225-A | Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists | GLAXO SMITHKLINE S P A (IT) | 2003-03-26 | — | — | CN | disclosed |