Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852412 | 0.81 | ADORA2A (0.35) | ADORA2AADORA1CYP2A6SCN9A | |
| SCHEMBL6847882 | 0.77 | MELK (0.35) | ADORA2AADORA1CYP2A6ALOX15HDAC1 | |
| SCHEMBL6850751 | 0.74 | ADORA2A (0.37) | ADORA2AADORA1CYP2A6HDAC1HDAC8 | |
| SCHEMBL6852026 | 0.71 | KDM4E (0.33) | CYP2A6 | |
| SCHEMBL6852505 | 0.70 | CYP2D6 (0.45) | CYP2A6HDAC1 | |
| SCHEMBL6874558 | 0.70 | ADORA2A (0.34) | ADORA2AADORA1CYP2A6HDAC1HDAC8 | |
| SCHEMBL6874568 | 0.70 | ADORA2A (0.34) | ADORA2AADORA1CYP2A6HDAC1HDAC8 | |
| SCHEMBL6847827 | 0.68 | MAPK8 (0.40) | ADORA2AADORA1CYP2A6HDAC1HDAC8 | |
| SCHEMBL6851800 | 0.66 | ADORA2A (0.35) | ADORA2AADORA1CYP2A6 | |
| SCHEMBL27711486 | 0.66 | BCAT2 (0.49) | ADORA2AADORA1CYP2A6ALOX15HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1585775-A | 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials | ORTHO MCNEIL PHARM INC (US) | 2005-02-23 | — | — | CN | disclosed |
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |