Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | MYC | P01106 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NEK2 | P51955 | 1/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | GRK6 | P43250 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852106 | 1.00 | ATM (0.42) | ATMERN1HDAC3HDAC1HDAC2 | |
| SCHEMBL6853998 | 0.81 | NEK2 (0.46) | ERN1HDAC3HDAC1HDAC2TP53 | |
| SCHEMBL6853995 | 0.81 | NEK2 (0.46) | ERN1HDAC3HDAC1HDAC2TP53 | |
| SCHEMBL6854756 | 0.81 | MKNK1 (0.50) | ERN1HDAC3HDAC1HDAC2CYP2A6 | |
| SCHEMBL6854752 | 0.81 | MKNK1 (0.50) | ERN1HDAC3HDAC1HDAC2CYP2A6 | |
| SCHEMBL6879593 | 0.79 | ATM (0.39) | ATMERN1HDAC3HDAC1HDAC2 | |
| SCHEMBL6879589 | 0.79 | ATM (0.39) | ATMERN1HDAC3HDAC1HDAC2 | |
| SCHEMBL6879587 | 0.79 | ATM (0.39) | ATMERN1HDAC3HDAC1HDAC2 | |
| SCHEMBL6852158 | 0.73 | CYP2D6 (0.42) | HDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL6852111 | 0.73 | CYP2D6 (0.42) | HDAC4NEK2PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1585775-A | 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials | ORTHO MCNEIL PHARM INC (US) | 2005-02-23 | — | — | CN | disclosed |
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |