Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | ERN1 | O75460 | 3/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | GRK6 | P43250 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.30 |
| ▸ | TEK | Q02763 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879593 | 1.00 | ATM (0.39) | ATMHDAC3HDAC1HDAC2ERN1 | |
| SCHEMBL6879589 | 1.00 | ATM (0.39) | ATMHDAC3HDAC1HDAC2ERN1 | |
| SCHEMBL6851704 | 0.82 | NEK2 (0.44) | HDAC3HDAC1HDAC2ERN1HDAC6 | |
| SCHEMBL6851702 | 0.82 | NEK2 (0.44) | HDAC3HDAC1HDAC2ERN1HDAC6 | |
| SCHEMBL6851701 | 0.82 | NEK2 (0.44) | HDAC3HDAC1HDAC2ERN1HDAC6 | |
| SCHEMBL6851676 | 0.82 | MKNK1 (0.54) | HDAC3HDAC1HDAC2ERN1CYP2A6 | |
| SCHEMBL6851680 | 0.82 | MKNK1 (0.54) | HDAC3HDAC1HDAC2ERN1CYP2A6 | |
| SCHEMBL6851674 | 0.82 | MKNK1 (0.54) | HDAC3HDAC1HDAC2ERN1CYP2A6 | |
| SCHEMBL6852103 | 0.79 | ATM (0.42) | ATMHDAC3HDAC1HDAC2ERN1 | |
| SCHEMBL6852106 | 0.79 | ATM (0.42) | ATMHDAC3HDAC1HDAC2ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |