SCHEMBL6852202

SCHEMBL6852202

Cn1nccc1-c1ccc(C#CC=O)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP19A1 P11511 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
KCNH2 Q12809 1/20 0.40
HRH3 Q9Y5N1 1/20 0.40
PDE10A Q9Y233 1/20 0.39
PORCN Q9H237 1/20 0.38
SLC13A5 Q86YT5 1/20 0.38
CD274 Q9NZQ7 1/20 0.37
PIK3CD O00329 1/20 0.37
PIK3CA P42336 1/20 0.37
PIK3CB P42338 1/20 0.37
PI4KA P42356 1/20 0.37
PIK3CG P48736 1/20 0.37
PI4KB Q9UBF8 1/20 0.37
COMT P21964 1/20 0.37
DRD1 P21728 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28561226 0.79 CYP1A2 (0.50) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9
SCHEMBL21258320 0.79 CYP1A2 (0.50) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9
SCHEMBL21258105 0.79 CYP1A2 (0.50) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9
SCHEMBL6852088 0.79 CYP1A2 (0.50) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9
SCHEMBL21258294 0.78 CYP1A2 (0.53) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9
SCHEMBL22779156 0.78 CYP1A2 (0.49) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9
SCHEMBL6852427 0.75 CYP1A2 (0.49) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9
SCHEMBL6852188 0.72 CYP1A2 (0.50) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9
SCHEMBL22779101 0.72 CYP1A2 (0.41) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9
SCHEMBL30564330 0.71 NOTUM (0.42) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6825170-B2 ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING ORTHO-MCNEIL PHARMACEUTICAL, INC. 2004-11-30 US disclosed
EP-1453847-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS Ortho-Mcneil Pharmaceutical, Inc. (US) 2004-09-08 EP disclosed
WO-2003050132-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2003-06-19 WO disclosed