Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674690 | 0.90 | PTGDR (0.31) | PTGDR2 | |
| SCHEMBL7673244 | 0.88 | MAPT (0.30) | HTR2AHTR2C | |
| SCHEMBL7676778 | 0.85 | HTR2C (0.37) | HTR2AHTR2CPTGDR2MCL1 | |
| SCHEMBL6851580 | 0.82 | MCL1 (0.32) | HTR2AHTR2CMCL1 | |
| SCHEMBL6853636 | 0.81 | PTGDR2 (0.49) | PTGDR2 | |
| SCHEMBL7673579 | 0.81 | HTR2A (0.38) | HTR2AHTR2CPTGDR2MCL1 | |
| Maleic Acid SCHEMBL6482229 | 0.78 | HTR2C (0.45) | HTR2AHTR2C | |
| SCHEMBL7679724 | 0.78 | HTR2A (0.36) | HTR2AHTR2CPTGDR2MCL1 | |
| SCHEMBL6497051 | 0.78 | HTR2A (0.34) | HTR2AHTR2CMCL1 | |
| SCHEMBL6847402 | 0.77 | HTR2C (0.53) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173440-B1 | TETRACYCLIC AZEPINOINDOLE COMPOUNDS AS 5-HT RECEPTOR LIGANDS | UPJOHN CO (US) | 2004-09-15 | — | — | EP | claimed |