SCHEMBL6852213

SCHEMBL6852213

OCC#Cc1csc(-c2cccnc2)c1

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 9/20 0.54
DYRK1B Q9Y463 8/20 0.54
MELK Q14680 1/20 0.44
DYRK2 Q92630 1/20 0.43
CYP2A6 P11509 5/20 0.43
DHPS P49366 1/20 0.43
CYP3A4 P08684 4/20 0.41
CYP2C9 P11712 3/20 0.41
CYP2B6 P20813 3/20 0.41
CYP2E1 P05181 2/20 0.41
CYP2C19 P33261 2/20 0.41
CLK1 P49759 1/20 0.40
HASPIN Q8TF76 1/20 0.40
GRM5 P41594 2/20 0.40
MKNK1 Q9BUB5 1/20 0.40
MKNK2 Q9HBH9 1/20 0.40
CYP2D6 P10635 1/20 0.40
ALDH1A1 P00352 1/20 0.39
CYP1A2 P05177 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6852612 0.81 DYRK1A (0.58) DYRK1ADYRK1BDYRK2CYP2A6CYP3A4
SCHEMBL6854314 0.77 MKNK1 (0.57) MELKCYP2A6CYP3A4CYP2C9CYP2B6
SCHEMBL27719516 0.77 DYRK1A (0.62) DYRK1ADYRK1BDYRK2CYP2A6CYP3A4
SCHEMBL6850738 0.77 DYRK1A (0.54) DYRK1ADYRK1BDYRK2CYP2A6DHPS
SCHEMBL6852526 0.77 DYRK1A (0.54) DYRK1ADYRK1BDYRK2CYP2A6CYP3A4
SCHEMBL2155811 0.74 CYP2A6 (0.67) MELKCYP2A6CYP3A4CYP2C9CYP2B6
SCHEMBL30938347 0.74 CYP2A6 (0.67) MELKCYP2A6CYP3A4CYP2C9CYP2B6
SCHEMBL6854221 0.74 KDM4E (0.42) MELKGRM5ALDH1A1CYP1A2
SCHEMBL6879818 0.74 CYP2A6 (0.56) CYP2A6CYP3A4CYP2C9CYP2B6CYP2E1
SCHEMBL3927813 0.72 DYRK1A (0.68) DYRK1ADYRK1BDYRK2CYP2A6CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6825170-B2 ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING ORTHO-MCNEIL PHARMACEUTICAL, INC. 2004-11-30 US disclosed
EP-1453847-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS Ortho-Mcneil Pharmaceutical, Inc. (US) 2004-09-08 EP disclosed
WO-2003050132-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2003-06-19 WO disclosed