SCHEMBL6879818

SCHEMBL6879818

OCC#Cc1ccc(-c2cccnc2)s1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 16/20 0.56
CYP2C19 P33261 10/20 0.49
CYP2C9 P11712 10/20 0.49
CYP3A4 P08684 10/20 0.49
CYP2E1 P05181 9/20 0.49
CYP2D6 P10635 8/20 0.49
CYP2B6 P20813 7/20 0.49
MKNK1 Q9BUB5 2/20 0.48
MKNK2 Q9HBH9 2/20 0.48
HDAC3 O15379 1/20 0.46
HDAC4 P56524 1/20 0.46
HDAC1 Q13547 1/20 0.46
HDAC7 Q8WUI4 1/20 0.46
HDAC2 Q92769 1/20 0.46
HDAC10 Q969S8 1/20 0.46
HDAC11 Q96DB2 1/20 0.46
HDAC8 Q9BY41 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
HDAC9 Q9UKV0 1/20 0.46
HDAC5 Q9UQL6 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6854759 0.84 MAPK14 (0.38) CYP2A6CYP2C19CYP2C9CYP3A4CYP2E1
SCHEMBL6847889 0.83 MAPK14 (0.51) CYP2A6CYP2C19CYP2C9CYP3A4CYP2E1
SCHEMBL6852131 0.80 CYP2A6 (0.53) CYP2A6CYP2C19CYP2C9CYP3A4CYP2E1
SCHEMBL6847879 0.79 MELK (0.37) CYP2A6CYP2C19CYP2C9CYP2D6CYP1A2
SCHEMBL6852526 0.77 DYRK1A (0.54) CYP2A6CYP2C19CYP2C9CYP3A4CYP2E1
SCHEMBL6854322 0.76 HDAC1 (0.41) HDAC1ALDH1A1MAPK14
SCHEMBL6847768 0.76 CYP2A6 (0.56) CYP2A6CYP2C19CYP2C9CYP3A4CYP2E1
SCHEMBL19745884 0.76 CYP2A6 (0.56) CYP2A6CYP2C19CYP2C9CYP3A4CYP2E1
SCHEMBL29854440 0.74 CYP2A6 (0.73) CYP2A6CYP2C19CYP2C9CYP3A4CYP2E1
SCHEMBL6869609 0.74 KDM4E (0.55) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6825170-B2 ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING ORTHO-MCNEIL PHARMACEUTICAL, INC. 2004-11-30 US disclosed