SCHEMBL6852446

SCHEMBL6852446

C#CCOc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl.C=CCOc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl

nearest known ligand 0.85

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CCR4 P51679 20/20 0.85

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1731604 0.93 CCR4 (0.72) CCR4
SCHEMBL1733167 0.92 CCR4 (1.00) CCR4
SCHEMBL1733390 0.78 CCR4 (0.74) CCR4
SCHEMBL1732735 0.78 CCR4 (0.78) CCR4
SCHEMBL1732492 0.77 CCR4 (1.00) CCR4
SCHEMBL1732999 0.77 CCR4 (0.81) CCR4
SCHEMBL1731858 0.77 CCR4 (0.79) CCR4
SCHEMBL7038787 0.76 CCR4 (0.76) CCR4
SCHEMBL1732312 0.75 CCR4 (1.00) CCR4
SCHEMBL1732437 0.75 CCR4 (0.76) CCR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1467976-A1 N-PYRAZINYL-PHENYLSULPHONAMIDES AND THEIR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASES AstraZeneca AB (SE) 2004-10-20 EP claimed
WO-2003059893-A1 N-PYRAZINYL-PHENYLSULPHONAMIDES AND THEIR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASES ASTRAZENECA AB (SE) 2003-07-24 WO claimed