Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGDS | O60760 | 15/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852587 | 1.00 | NPC1 (0.47) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL6852590 | 1.00 | NPC1 (0.47) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL6852121 | 0.81 | NPC1 (0.48) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL6852124 | 0.81 | NPC1 (0.48) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL6854217 | 0.80 | HDAC4 (0.35) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6881060 | 0.80 | HDAC4 (0.35) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6881056 | 0.80 | HDAC4 (0.35) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6879073 | 0.79 | ADRB2 (0.42) | NPC1RAB9A | |
| SCHEMBL6276439 | 0.79 | ADRB2 (0.42) | NPC1RAB9A | |
| SCHEMBL6309957 | 0.79 | ADRB2 (0.42) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |