Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 9/20 | 0.39 |
| ▸ | DRD3 | P35462 | 5/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653411 | 1.00 | HTR2A (0.41) | HTR2ADRD4KDM4EDRD2DRD3 | |
| SCHEMBL654486 | 0.99 | HTR2A (0.42) | HTR2ADRD4KDM4EDRD2DRD3 | |
| SCHEMBL654976 | 0.92 | DRD2 (0.39) | HTR2ADRD4DRD2DRD3CCR3 | |
| SCHEMBL654978 | 0.92 | DRD2 (0.39) | HTR2ADRD4DRD2DRD3CCR3 | |
| SCHEMBL653953 | 0.91 | DRD2 (0.40) | HTR2ADRD4DRD2CCR1ADRA1A | |
| SCHEMBL653951 | 0.91 | DRD2 (0.40) | HTR2ADRD4DRD2CCR1ADRA1A | |
| SCHEMBL655932 | 0.90 | DRD2 (0.38) | HTR2ADRD4DRD2DRD3CCR3 | |
| SCHEMBL652406 | 0.89 | DRD2 (0.38) | HTR2ADRD4DRD2CCR3CCR1 | |
| SCHEMBL652404 | 0.89 | DRD2 (0.38) | HTR2ADRD4DRD2CCR3CCR1 | |
| SCHEMBL653964 | 0.89 | DRD2 (0.40) | HTR2ADRD4DRD2CCR3CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448566-A2 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003045942-A2 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-06-05 | — | — | WO | disclosed |