Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 8/20 | 0.61 |
| ▸ | AKR1C1 | Q04828 | 8/20 | 0.61 |
| ▸ | ERN1 | O75460 | 3/20 | 0.51 |
| ▸ | EIF4E | P06730 | 1/20 | 0.51 |
| ▸ | DHODH | Q02127 | 3/20 | 0.50 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | ACLY | P53396 | 1/20 | 0.48 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6849618 | 0.86 | DHODH (0.51) | AKR1C2ERN1EIF4EDHODHAKR1C3 | |
| SCHEMBL11692771 | 0.85 | AKR1C2 (0.50) | AKR1C2AKR1C1EIF4EAKR1C4AKR1C3 | |
| SCHEMBL6850839 | 0.81 | AKR1C2 (0.71) | AKR1C2AKR1C1DHODHAKR1C4AKR1C3 | |
| SCHEMBL31721571 | 0.80 | DHODH (0.53) | ERN1DHODHMCL1 | |
| SCHEMBL3564439 | 0.78 | MAP4K1 (0.60) | — | |
| SCHEMBL3488761 | 0.77 | AKR1C2 (0.45) | AKR1C2AKR1C1EIF4EDHODHACLY | |
| SCHEMBL11228183 | 0.77 | AKR1C2 (1.00) | AKR1C2AKR1C1AKR1C4AKR1C3MCL1 | |
| SCHEMBL27722168 | 0.75 | HPGD (0.54) | ERN1DHODHCLCN2MCL1 | |
| SCHEMBL10024254 | 0.75 | DHODH (0.56) | AKR1C2EIF4EDHODHAKR1C3MCL1 | |
| SCHEMBL13602473 | 0.74 | DHODH (0.53) | AKR1C2EIF4EDHODHAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294378-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2004-01-28 | — | — | EP | claimed |
| EP-1294378-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-26 | — | — | EP | claimed |
| WO-2001089457-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-29 | — | — | WO | claimed |
| EP-1294378-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2004-01-28 | — | — | EP | disclosed |
| EP-1294378-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001089457-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-29 | — | — | WO | disclosed |