Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 7/20 | 0.66 |
| ▸ | TACR3 | P29371 | 13/20 | 0.61 |
| ▸ | TACR2 | P21452 | 9/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5945344 | 0.89 | TRPV4 (0.80) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6853726 | 0.88 | TACR3 (0.60) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6853853 | 0.84 | TRPV4 (0.62) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL5945431 | 0.82 | TRPV4 (0.75) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6397765 | 0.80 | TRPV4 (0.71) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6855974 | 0.78 | TACR3 (0.70) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6398523 | 0.78 | TRPV4 (0.68) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL5203642 | 0.77 | TRPV4 (0.73) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL5945397 | 0.76 | TACR3 (0.77) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL5732536 | 0.76 | TACR2 (0.71) | TRPV4TACR3TACR2OPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | claimed |
| CN-1407850-A | Process for converting storage reserves of dicot seeds into compositions comprising one or more gene products | UNICROP LTD (FI) | 2003-04-02 | — | — | CN | disclosed |
| CN-1406225-A | Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists | GLAXO SMITHKLINE S P A (IT) | 2003-03-26 | — | — | CN | disclosed |