Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 8/20 | 0.37 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6853781 | 1.00 | NR1H2 (0.48) | NR1H2CHRM2CHRM1CHRM3SRC | |
| SCHEMBL16584744 | 0.86 | NR1H2 (0.55) | NR1H2CHRM2CHRM1CHRM3SRC | |
| SCHEMBL30700528 | 0.86 | NR1H2 (0.55) | NR1H2CHRM2CHRM1CHRM3SRC | |
| SCHEMBL610130 | 0.86 | NR1H2 (0.55) | NR1H2CHRM2CHRM1CHRM3SRC | |
| SCHEMBL13336742 | 0.86 | NR1H2 (0.55) | NR1H2CHRM2CHRM1CHRM3SRC | |
| SCHEMBL261611 | 0.86 | NR1H2 (0.55) | NR1H2CHRM2CHRM1CHRM3SRC | |
| SCHEMBL19390033 | 0.86 | NR1H2 (0.55) | NR1H2CHRM2CHRM1CHRM3SRC | |
| SCHEMBL29007981 | 0.85 | NR1H2 (0.51) | NR1H2CHRM2CHRM1CHRM3SRC | |
| SCHEMBL29035448 | 0.85 | NR1H2 (0.51) | NR1H2CHRM2CHRM1CHRM3SRC | |
| SCHEMBL11099691 | 0.82 | NR1H2 (0.49) | NR1H2CHRM2CHRM1CHRM3SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828427-B1 | Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same | ISIS PHARMACEUTICALS, INC. | 2004-12-07 | — | — | US | disclosed |
| EP-0865439-A4 | COMBINATORIAL LIBRARIES HAVING AMINODIOL MONOMER SUBUNITS | ISIS PHARMACEUTICALS INC (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0865439-A1 | COMBINATORIAL LIBRARIES HAVING AMINODIOL MONOMER SUBUNITS | ISIS PHARMACEUTICALS, INC. (US) | 1998-09-23 | — | — | EP | disclosed |
| WO-1996040672-A1 | COMBINATORIAL LIBRARIES HAVING AMINODIOL MONOMER SUBUNITS | ISIS PHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |