SCHEMBL6854035

SCHEMBL6854035

O=CC#Cc1ccc(-c2ccncn2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 2/20 0.45
MAPT P10636 1/20 0.37
GRM5 P41594 3/20 0.35
CAMKK2 Q96RR4 1/20 0.35
HDAC4 P56524 1/20 0.34
GSK3B P49841 5/20 0.33
MAPK10 P53779 2/20 0.33
MAPK14 Q16539 2/20 0.33
MAPK9 P45984 3/20 0.32
MAPK11 Q15759 1/20 0.32
ROCK1 Q13464 2/20 0.32
PRKACA P17612 2/20 0.32
CLK4 Q9HAZ1 2/20 0.32
ROCK2 O75116 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32
PRKCG P05129 1/20 0.32
RPS6KB1 P23443 1/20 0.32
MAPK1 P28482 1/20 0.32
GSK3A P49840 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6848148 0.79 MAPT (0.44) CYP2D6MAPTGRM5CYP3A4
SCHEMBL6852214 0.79 CYP1A2 (0.44) CYP2D6CYP2C9MAPK1
SCHEMBL6847956 0.78 CYP2D6 (0.49) CYP2D6MAPTGRM5CAMKK2HDAC4
SCHEMBL6852505 0.77 CYP2D6 (0.45) CYP2D6MAPTHDAC4CYP3A4CYP2C9
SCHEMBL9903935 0.76 CYP2D6 (0.60) CYP2D6MAPTGRM5CAMKK2HDAC4
SCHEMBL6847782 0.75 CYP3A4 (0.36) CYP2D6MAPTGRM5CAMKK2GSK3B
SCHEMBL6854131 0.74 CYP2D6 (0.49) CYP2D6MAPTGRM5CAMKK2HDAC4
SCHEMBL24791664 0.74 GRM5 (0.54) CYP2D6GRM5GSK3BGSK3AMAP4K4
SCHEMBL5798370 0.74 CYP2D6 (0.47) CYP2D6MAPTCAMKK2HDAC4GSK3B
SCHEMBL30872091 0.74 GRM5 (0.54) CYP2D6GRM5GSK3BGSK3AMAP4K4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1585775-A 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials ORTHO MCNEIL PHARM INC (US) 2005-02-23 CN disclosed
US-6825170-B2 ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING ORTHO-MCNEIL PHARMACEUTICAL, INC. 2004-11-30 US disclosed
EP-1453847-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS Ortho-Mcneil Pharmaceutical, Inc. (US) 2004-09-08 EP disclosed
WO-2003050132-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2003-06-19 WO disclosed