Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 13/20 | 0.50 |
| ▸ | GSK3B | P49841 | 4/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.50 |
| ▸ | CDK1 | P06493 | 3/20 | 0.50 |
| ▸ | PIM1 | P11309 | 3/20 | 0.50 |
| ▸ | PRKACA | P17612 | 3/20 | 0.50 |
| ▸ | CLK2 | P49760 | 3/20 | 0.50 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.50 |
| ▸ | PRKX | P51817 | 3/20 | 0.50 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.50 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.50 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.50 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.50 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6854693 | 1.00 | AKT1 (0.50) | AKT1GSK3BDYRK1APRKD3CDK1 | |
| SCHEMBL6853191 | 0.90 | AKT1 (0.54) | AKT1GSK3BDYRK1APRKD3CDK1 | |
| SCHEMBL6853195 | 0.90 | AKT1 (0.54) | AKT1GSK3BDYRK1APRKD3CDK1 | |
| SCHEMBL6854880 | 0.86 | AKT1 (0.54) | AKT1GSK3BDYRK1APRKD3CDK1 | |
| SCHEMBL6854874 | 0.86 | AKT1 (0.54) | AKT1GSK3BDYRK1APRKD3CDK1 | |
| SCHEMBL31584143 | 0.78 | CTSB (0.46) | AKT1ROCK2ROCK1 | |
| SCHEMBL6854987 | 0.78 | AAK1 (0.47) | AAK1 | |
| SCHEMBL6855122 | 0.78 | AAK1 (0.47) | AAK1 | |
| SCHEMBL14005204 | 0.78 | AAK1 (0.40) | AAK1 | |
| SCHEMBL6830518 | 0.77 | AAK1 (0.38) | AKT1GSK3BDYRK1APRKD3CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831175-B2 | Such as N,N-dimethyl-N-(2-((5-((E)-2-pyridin-4-ylvinyl) pyridin-3-yl)oxy)ethyl)amine | ABBOTT LABORATORIES | 2004-12-14 | — | — | US | disclosed |
| US-20030199511-A1 | Kinase inhibitors | ABBVIE INC. | 2003-10-23 | — | — | US | disclosed |
| US-20030187026-A1 | Kinase inhibitors | ABBOTT LABORATORIES | 2003-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187026-A1 | Kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | AKT1 119/4885GSK3B 442/4885DYRK1A 1054/4885 |
| US-20030199511-A1 | Kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | AKT1 119/4885GSK3B 442/4885DYRK1A 1054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.