SCHEMBL6854919

SCHEMBL6854919

[CH2]C#Cc1ccc2ccccc2n1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 3/20 0.59
KCNH2 Q12809 3/20 0.59
TTR P02766 1/20 0.50
NCF1 P14598 3/20 0.43
CYP1A2 P05177 2/20 0.43
NOS2 P35228 1/20 0.43
BACE1 P56817 1/20 0.43
CA12 O43570 1/20 0.43
CA9 Q16790 1/20 0.43
ALDH1A1 P00352 4/20 0.39
HPGD P15428 3/20 0.39
MAPT P10636 2/20 0.39
GLA P06280 1/20 0.39
ACHE P22303 1/20 0.39
MGAM O43451 1/20 0.38
NPC1 O15118 6/20 0.38
RAB9A P51151 6/20 0.38
PKM P14618 3/20 0.38
KDM4E B2RXH2 2/20 0.38
TP53 P04637 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12884286 0.79 GRM5 (0.65) GRM5KCNH2TTRNCF1CYP1A2
SCHEMBL30824514 0.79 GRM5 (0.59) GRM5KCNH2TTRNCF1CYP1A2
SCHEMBL18751060 0.79 GRM5 (0.59) GRM5KCNH2TTRNCF1CYP1A2
SCHEMBL1779078 0.78 GRM5 (0.53) GRM5KCNH2TTRNCF1CYP1A2
SCHEMBL5778843 0.78 GRM5 (0.62) GRM5KCNH2TTRNCF1CYP1A2
SCHEMBL5099192 0.76 GRM5 (0.61) GRM5KCNH2TTRNCF1CYP1A2
Ethylene SCHEMBL4594450 0.75 GRM5 (0.50) GRM5KCNH2TTRNCF1CYP1A2
SCHEMBL15877252 0.75 GRM5 (1.00) GRM5KCNH2TTRCYP1A2ALDH1A1
SCHEMBL12884290 0.75 TTR (0.62) GRM5KCNH2TTRNCF1CYP1A2
SCHEMBL6847920 0.75 GRM5 (0.54) GRM5KCNH2TTRNCF1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1585775-A 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials ORTHO MCNEIL PHARM INC (US) 2005-02-23 CN disclosed
US-6825170-B2 ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING ORTHO-MCNEIL PHARMACEUTICAL, INC. 2004-11-30 US disclosed
EP-1453847-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS Ortho-Mcneil Pharmaceutical, Inc. (US) 2004-09-08 EP disclosed
EP-1343798-A1 6-O-CARBAMOYL KETOLIDE DERIVATIVES OF ERYTHROMYCIN USEFUL AS ANTIBACTERIALS Ortho-Mcneil Pharmaceutical, Inc. (US) 2003-09-17 EP disclosed
WO-2003050132-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2003-06-19 WO disclosed
WO-2002046204-A1 6-0-CARBAMOYL KETOLIDE DERIVATIVES OF ERYTHROMYCIN USEFUL AS ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2002-06-13 WO disclosed