Ethylene

Ethylene

SCHEMBL4594450

C=C.N#Cc1ccc2ccccc2n1

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 1/20 0.50
KCNH2 Q12809 1/20 0.50
NQO1 P15559 1/20 0.49
SOS2 Q07890 1/20 0.47
NCF1 P14598 3/20 0.43
CYP1A2 P05177 2/20 0.43
NOS2 P35228 1/20 0.43
BACE1 P56817 1/20 0.43
CA12 O43570 1/20 0.43
CA9 Q16790 1/20 0.43
KDM4E B2RXH2 4/20 0.43
ALDH1A1 P00352 4/20 0.43
GAA P10253 1/20 0.43
TTR P02766 1/20 0.42
GLA P06280 1/20 0.39
MAPT P10636 1/20 0.39
HPGD P15428 1/20 0.39
ACHE P22303 1/20 0.39
MGAM O43451 1/20 0.38
SRC P12931 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29359679 0.96 GRM5 (0.53) GRM5KCNH2NQO1SOS2NCF1
SCHEMBL75226 0.96 GRM5 (0.53) GRM5KCNH2NQO1SOS2NCF1
SCHEMBL27416745 0.96 GRM5 (0.53) GRM5KCNH2NQO1SOS2NCF1
Methane SCHEMBL27560165 0.94 GRM5 (0.52) GRM5KCNH2NQO1SOS2NCF1
Hydrochloric Acid SCHEMBL28328423 0.94 GRM5 (0.52) GRM5KCNH2NQO1SOS2NCF1
Hydrazine SCHEMBL28226443 0.92 GRM5 (0.50) GRM5KCNH2NQO1SOS2NCF1
Ethane SCHEMBL28069598 0.92 NQO1 (0.53) GRM5KCNH2NQO1SOS2NCF1
SCHEMBL15877631 0.85 GRM5 (0.62) GRM5KCNH2NQO1SOS2NCF1
Quinoline SCHEMBL28130812 0.85 ALDH1A1 (0.61) GRM5KCNH2NQO1SOS2NCF1
Pyrrole SCHEMBL28298992 0.85 GRM5 (0.45) GRM5KCNH2NQO1SOS2NCF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1879563-A4 NOVEL CHEMICAL COMPOUNDS SMITHKLINE BEECHAM CORP (US) 2008-07-16 EP disclosed
EP-1879563-A2 NOVEL CHEMICAL COMPOUNDS Smithkline Beecham Corporation (US) 2008-01-23 EP disclosed
WO-2006132739-A2 NOVEL CHEMICAL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2006-12-14 WO disclosed