Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.48 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.48 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CHKA | P35790 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10123162 | 1.00 | HPGD (0.64) | HPGDALDH1A1TSHRCHRNB2CHRNA3 | |
| SCHEMBL2672409 | 0.98 | HPGD (0.60) | HPGDALDH1A1TSHRCHRNB2CHRNA3 | |
| SCHEMBL2672842 | 0.93 | HPGD (0.54) | HPGDALDH1A1TSHRCHRNB2CHRNA3 | |
| SCHEMBL7894706 | 0.84 | CHRNB2 (0.62) | HPGDALDH1A1TSHRCHRNB2CHRNA3 | |
| SCHEMBL319228 | 0.82 | HPGD (0.59) | HPGDALDH1A1TSHRCHRNB2CHRNA3 | |
| SCHEMBL19309532 | 0.82 | CHRNB2 (0.72) | HPGDALDH1A1TSHRCHRNB2CHRNA3 | |
| SCHEMBL30859982 | 0.82 | CHRNB2 (0.65) | HPGDALDH1A1TSHRCHRNB2CHRNA3 | |
| SCHEMBL2146125 | 0.81 | HPGD (0.57) | HPGDALDH1A1TSHRCHRNB2CHRNA3 | |
| SCHEMBL2146130 | 0.81 | HPGD (0.57) | HPGDALDH1A1TSHRCHRNB2CHRNA3 | |
| SCHEMBL2673961 | 0.81 | HPGD (0.57) | HPGDALDH1A1TSHRCHRNB2CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283428-A1 | HETEROCYCLOALKYL AND HETEROARYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THAT MODULATE IKZF2 | Plexium, Inc. (US) | 2023-01-12 | — | — | WO | disclosed |
| WO-2013010380-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-01-24 | — | — | WO | disclosed |
| WO-2011096461-A1 | QUINOLINE DERIVATIVE | 大正製薬株式会社 (JP) | 2011-08-11 | — | — | WO | disclosed |