Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | ANXA2 | P07355 | 2/20 | 0.35 |
| ▸ | S100A10 | P60903 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6856860 | 1.00 | MAPT (0.40) | MAPTTP53DHFRKMT2ALMNA | |
| SCHEMBL6854862 | 0.93 | MAPT (0.40) | MAPTTP53DHFRKMT2ALMNA | |
| SCHEMBL6854856 | 0.93 | MAPT (0.40) | MAPTTP53DHFRKMT2ALMNA | |
| SCHEMBL6850099 | 0.92 | MAPT (0.40) | MAPTTP53DHFRKMT2ALMNA | |
| SCHEMBL6850102 | 0.92 | MAPT (0.40) | MAPTTP53DHFRKMT2ALMNA | |
| SCHEMBL6854858 | 0.88 | MAPT (0.42) | MAPTTP53LMNAHTTGAA | |
| SCHEMBL6854863 | 0.88 | MAPT (0.42) | MAPTTP53LMNAHTTGAA | |
| SCHEMBL7536162 | 0.87 | TP53 (0.41) | MAPTTP53DHFRKMT2ALMNA | |
| SCHEMBL7536159 | 0.87 | TP53 (0.41) | MAPTTP53DHFRKMT2ALMNA | |
| SCHEMBL6853754 | 0.84 | MAPT (0.54) | MAPTTP53KMT2ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828315-B1 | Anti- inflammatories, anti-allergics, bronchodilatators, anti-asthmatics, or TNF alpha inhibitors | WARNER-LAMBERT LLC | 2004-12-07 | — | — | US | claimed |
| US-6828315-B1 | Anti- inflammatories, anti-allergics, bronchodilatators, anti-asthmatics, or TNF alpha inhibitors | WARNER-LAMBERT LLC | 2004-12-07 | — | — | US | disclosed |
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | disclosed |