Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | DHFR | P00374 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7536162 | 1.00 | TP53 (0.41) | TP53MAPTDHFRKMT2ALMNA | |
| SCHEMBL6850102 | 0.95 | MAPT (0.40) | TP53MAPTDHFRKMT2ALMNA | |
| SCHEMBL6850099 | 0.95 | MAPT (0.40) | TP53MAPTDHFRKMT2ALMNA | |
| SCHEMBL6855354 | 0.95 | DHFR (0.40) | TP53MAPTDHFRLMNAPOLB | |
| SCHEMBL6855359 | 0.95 | DHFR (0.40) | TP53MAPTDHFRLMNAPOLB | |
| SCHEMBL6854862 | 0.94 | MAPT (0.40) | TP53MAPTDHFRKMT2ALMNA | |
| SCHEMBL6854856 | 0.94 | MAPT (0.40) | TP53MAPTDHFRKMT2ALMNA | |
| SCHEMBL6856860 | 0.87 | MAPT (0.40) | TP53MAPTDHFRKMT2ALMNA | |
| SCHEMBL6856865 | 0.87 | MAPT (0.40) | TP53MAPTDHFRKMT2ALMNA | |
| SCHEMBL6850045 | 0.85 | DPP4 (0.33) | TP53MAPTDHFRKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002022112-A9 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING A DISEASE ASSOCIATED WITH AN EXCESS OF IL-12 PRODUCTION | WARNER LAMBERT CO (US) | 2002-06-06 | — | — | WO | disclosed |