Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KLK7 | P49862 | 4/20 | 0.30 |
| ▸ | KLK5 | Q9Y337 | 4/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.30 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476247 | 0.79 | PDE4D (0.35) | CNR2PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6856969 | 0.77 | CNR2 (0.32) | CNR2PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL74898 | 0.77 | PDK4 (0.42) | CNR2PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7495078 | 0.75 | PDK4 (0.39) | CNR2PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7494927 | 0.73 | USP2 (0.38) | CNR2PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7468708 | 0.72 | PDE4D (0.33) | CNR2PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2649144 | 0.67 | GPR119 (0.37) | CNR2PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL31640445 | 0.66 | GPR119 (0.53) | MEN1KMT2AMAPTGPR119ALDH1A1 | |
| SCHEMBL16427394 | 0.65 | GPR119 (0.54) | MEN1KMT2AMAPTGPR119ALDH1A1 | |
| SCHEMBL28927867 | 0.65 | CKS1B (0.51) | CNR2MAPTGPR119ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828332-B1 | Antagonists and partial agonists of the serotonin receptor, and activity as inhibitors of serotonin reuptake for treatment of depression | ELI LILLY AND COMPANY | 2004-12-07 | — | — | US | disclosed |
| US-6664274-B1 | 4-(4-benzothiophene- or 4-benzofuran-1,2,3,6-tetrahydro-pyridyl)- derivatives; 5-HT1A and 5-HT2A receptor antagonists; tobacco or nicotine withdrawal | ELI LILLY AND COMPANY | 2003-12-16 | — | — | US | disclosed |
| EP-0982304-B1 | Piperidine derivatives having effects on serotonin related systems | LILLY CO ELI (US) | 2002-10-02 | — | — | EP | disclosed |
| US-6436964-B1 | HETEROCYCLIC AMINES, USED AS SERETONIN REUPTAKE INHIBITORS AND RECEPTOR ANTAGONISTS, ANTIDEPRESSANTS | ELI LILLY AND COMPANY | 2002-08-20 | — | — | US | disclosed |
| EP-1220853-A1 | PIPERIDINE DERIVATIVES AS SEROTONINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-07-10 | — | — | EP | disclosed |
| EP-1146045-A1 | Piperidine derivatives having effects on serotonin related systems | ELI LILLY AND COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2001023380-A1 | PIPERIDINE DERIVATIVES AS SEROTONINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-04-05 | — | — | WO | disclosed |
| WO-2001023381-A1 | PIPERIDINE DERIVATIVES AS REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-04-05 | — | — | WO | disclosed |
| EP-0982304-A1 | Piperidine derivatives having effects on serotonin related systems | ELI LILLY AND COMPANY (US) | 2000-03-01 | — | — | EP | disclosed |
| WO-2000000198-A1 | PIPERIDINE DERIVATIVES HAVING EFFECTS ON SEROTONIN RELATED SYSTEMS | ELI LILLY AND COMPANY (US) | 2000-01-06 | — | — | WO | disclosed |