Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 1.00 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 4/20 | 0.43 |
| ▸ | FLT3 | P36888 | 3/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | FLT4 | P35916 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6857443 | 1.00 | KDR (1.00) | KDRCHEK1RETFLT3ALK | |
| SCHEMBL6088744 | 0.86 | KDR (0.76) | KDRCHEK1RETFLT3ALK | |
| SCHEMBL6088755 | 0.86 | KDR (0.76) | KDRCHEK1RETFLT3ALK | |
| SCHEMBL6090121 | 0.83 | KDR (0.71) | KDRCHEK1RETFLT3ALK | |
| SCHEMBL6090112 | 0.83 | KDR (0.71) | KDRCHEK1RETFLT3ALK | |
| SCHEMBL6090180 | 0.81 | KDR (0.68) | KDRCHEK1CYP1A2 | |
| SCHEMBL6090168 | 0.81 | KDR (0.68) | KDRCHEK1CYP1A2 | |
| SCHEMBL6088788 | 0.80 | KDR (0.76) | KDRRETFLT3ALKABL1 | |
| SCHEMBL6088783 | 0.80 | KDR (0.76) | KDRRETFLT3ALKABL1 | |
| SCHEMBL6090731 | 0.77 | KDR (0.77) | KDRCHEK1RETFLT3ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080125362-A1 | Method of screening compound preventing cells from infection with Hepatitis C virus (HCV) | JAPAN TOBACCO INC. (JP) | 2008-05-29 | — | — | US | disclosed |
| US-20080125362-A1 | Method of screening compound preventing cells from infection with Hepatitis C virus (HCV) | JAPAN TOBACCO INC. (JP) | 2008-05-29 | — | — | US | disclosed |
| US-6831075-B2 | Administering to a host for inhibiting kinase activity a 5-heterocylcic subustituted pyrazolone derivative | CEPHALON, INC. | 2004-12-14 | — | — | US | disclosed |
| US-20030162775-A1 | Heterocyclic substituted pyrazolones | CEPHALON, INC. | 2003-08-28 | — | — | US | disclosed |
| US-6455525-B1 | Heterocyclic substituted pyrazolones | CEPHALON, INC. | 2002-09-24 | — | — | US | disclosed |
| EP-1226141-A1 | HETEROCYCLIC SUBSTITUTED PYRAZOLONES | CEPHALON, INC. (US) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001032653-A1 | HETEROCYCLIC SUBSTITUTED PYRAZOLONES | CEPHALON, INC. (US) | 2001-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162775-A1 | Heterocyclic substituted pyrazolones | CYP3A4, CYP3A5, PDXK | KDR 3412/4885CHEK1 1374/4885RET 1073/4885 |
| US-20080125362-A1 | Method of screening compound preventing cells from infection with Hepatitis C virus (HCV) | HAVCR2, FGFR1, FGFR2 | KDR 566/4885CHEK1 1696/4885RET 492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.