SCHEMBL6858019

SCHEMBL6858019

N#Cc1ccccc1NC(=O)C(=O)Nc1ccccc1C#N

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 6/20 0.66
ALDH1A1 P00352 4/20 0.66
L3MBTL1 Q9Y468 3/20 0.66
KDM4E B2RXH2 5/20 0.66
TSHR P16473 1/20 0.58
GLA P06280 1/20 0.58
CYP1A2 P05177 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
PDK1 Q15118 1/20 0.57
PDK2 Q15119 1/20 0.57
PDK3 Q15120 1/20 0.57
PDK4 Q16654 1/20 0.57
KMT2A Q03164 3/20 0.54
MEN1 O00255 2/20 0.54
ALOX15 P16050 1/20 0.54
HSD17B10 Q99714 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
HPGD P15428 1/20 0.53
CA12 O43570 1/20 0.53
CA1 P00915 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11786623 0.90 GAA (0.65) GAAALDH1A1L3MBTL1KDM4ETSHR
SCHEMBL11789215 0.89 GAA (0.63) GAAALDH1A1L3MBTL1KDM4ETSHR
SCHEMBL11789221 0.87 GAA (0.57) GAAALDH1A1L3MBTL1KDM4ETSHR
SCHEMBL31598583 0.87 GAA (0.57) GAAALDH1A1L3MBTL1KDM4ETSHR
SCHEMBL30107521 0.86 GAA (0.64) GAAALDH1A1L3MBTL1KDM4ETSHR
SCHEMBL4766358 0.86 GAA (0.69) GAAALDH1A1L3MBTL1KDM4ETSHR
SCHEMBL6222692 0.86 GAA (0.64) GAAALDH1A1L3MBTL1KDM4ETSHR
SCHEMBL13756099 0.86 GAA (0.60) GAAALDH1A1L3MBTL1KDM4ETSHR
SCHEMBL18415554 0.86 GAA (0.73) GAAALDH1A1L3MBTL1KDM4ETSHR
SCHEMBL29769835 0.84 L3MBTL1 (0.63) GAAALDH1A1L3MBTL1KDM4ETSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6737193-B2 ACTIVE MATERIALS IN THE POSITIVE ELECTRODES OF BATTERIES. NOVEL METHODS FOR PREPARING THE TETRAKETOPIPERAZINE UNIT-CONTAINING COMPOUNDS INCLUDE: (I) REACTING AN OXALYL HALIDE AND AN OXAMIDE, AND ADDING WATER OR AN AQUEOUS ALKALI IM&T RESEARCH, INC. 2004-05-18 US disclosed
US-20030148188-A1 Active materials in the positive electrodes of batteries. Novel methods for preparing the tetraketopiperazine unit-containing compounds include: (i) reacting an oxalyl halide and an oxamide, and adding water or an aqueous alkali IM&T RESEARCH, INC. 2003-08-07 US disclosed