SCHEMBL6858302

SCHEMBL6858302

C[Si](C)(C)C#Cc1csc(Cl)n1

nearest known ligand 0.46

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 12/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1243386 0.79 GRM5 (0.56) GRM5
SCHEMBL4150082 0.78 GRM5 (0.46) GRM5
SCHEMBL22610105 0.78 GRM5 (0.35) GRM5
SCHEMBL26031108 0.73 GRM5 (0.33) GRM5
SCHEMBL3901343 0.73 GRM5 (0.33) GRM5
SCHEMBL578302 0.72 GRM5 (0.33) GRM5
SCHEMBL1646434 0.71
SCHEMBL691095 0.71
SCHEMBL31487982 0.71 GRM5 (0.33) GRM5
SCHEMBL592502 0.71 GRM5 (0.45) GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114555620-A Novel galactoside inhibitors of galectins 格莱克特生物技术公司 2022-05-27 CN disclosed
EP-3993870-A1 NOVEL GALACTOSIDE INHIBITOR OF GALECTINS Galecto Biotech AB (DK) 2022-05-11 EP disclosed
US-20110098326-A1 2-FLUOROTHIAZOLE DERIVATIVES USEFUL AS IMAGING AGENTS; METHODS OF SYNTHESIS, AND METHODS OF USE THE GOV. OF THE U.S.A. AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH AND HUMAN SERVICES 2011-04-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110098326-A1 2-FLUOROTHIAZOLE DERIVATIVES USEFUL AS IMAGING AGENTS; METHODS OF SYNTHESIS, AND METHODS OF USE GRM5, GRIK5, GRM2 GRM5 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.