Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 8/20 | 0.50 |
| ▸ | EDNRA | P25101 | 7/20 | 0.50 |
| ▸ | FABP4 | P15090 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | YWHAH | Q04917 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27580253 | 0.89 | EDNRB (0.41) | EDNRBEDNRAPLA2G2AALDH1A1PKM | |
| SCHEMBL6857506 | 0.77 | EDNRB (0.52) | EDNRBEDNRAFABP4TP53 | |
| SCHEMBL6855189 | 0.74 | DRD4 (0.53) | EDNRBEDNRAMAPT | |
| SCHEMBL7188348 | 0.74 | EDNRB (0.64) | EDNRBEDNRAFABP4PLA2G2AALDH1A1 | |
| SCHEMBL6307109 | 0.74 | EDNRB (0.64) | EDNRBEDNRAFABP4PLA2G2AALDH1A1 | |
| SCHEMBL6851233 | 0.73 | MAPT (0.53) | EDNRBEDNRAALDH1A1MAPT | |
| SCHEMBL6858314 | 0.71 | MAPT (0.48) | EDNRBEDNRAFABP4MAPTTP53 | |
| SCHEMBL6859418 | 0.71 | PPARG (0.47) | FABP4MAPTTP53MEN1KMT2A | |
| SCHEMBL6858334 | 0.69 | EDNRB (0.62) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL6851276 | 0.69 | EDNRB (0.52) | EDNRBEDNRAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6787651-B2 | 2-CARBOXY-SUBSTITUTED; TREATING OSTEOPENIA, OSTEOPOROSIS, CANCER, DIABETES AND ATHEROSCLEROSIS. | SMITHKLINE BEECHAM CORPORATION | 2004-09-07 | — | — | US | disclosed |
| US-20030087902-A1 | Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR-gamma binding agents | SMITHKLINE BEECHAM CORPORATION | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087902-A1 | Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR-gamma binding agents | PPARG, PPARA, PPARD | EDNRB 170/4885EDNRA 98/4885FABP4 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.