Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 3/20 | 0.64 |
| ▸ | EDNRA | P25101 | 3/20 | 0.64 |
| ▸ | CCR2 | P41597 | 2/20 | 0.54 |
| ▸ | FABP4 | P15090 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | YWHAH | Q04917 | 1/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TSPO | P30536 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6307109 | 0.86 | EDNRB (0.64) | EDNRBEDNRACCR2FABP4KMT2A | |
| SCHEMBL28283556 | 0.84 | FOLH1 (0.62) | EDNRBEDNRACCR2KMT2AALDH1A1 | |
| SCHEMBL27505541 | 0.81 | F10 (0.54) | EDNRBEDNRAKMT2AALDH1A1PLA2G2A | |
| SCHEMBL29093447 | 0.79 | KMT2A (0.62) | EDNRBEDNRAKMT2AALDH1A1TP53 | |
| SCHEMBL30616062 | 0.79 | KMT2A (0.62) | EDNRBEDNRAKMT2AALDH1A1TP53 | |
| SCHEMBL13062129 | 0.79 | HCAR3 (0.55) | EDNRBEDNRACCR2FABP4KMT2A | |
| SCHEMBL6632096 | 0.78 | EDNRA (1.00) | EDNRBEDNRACCR2KMT2AYWHAH | |
| SCHEMBL21365454 | 0.77 | P2RX4 (0.72) | KMT2AALDH1A1TP53POLBTSPO | |
| SCHEMBL27746490 | 0.76 | EDNRB (0.53) | EDNRBEDNRACCR2FABP4KMT2A | |
| SCHEMBL13015139 | 0.76 | P2RX4 (0.59) | EDNRBEDNRACCR2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341761-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-$g(g) BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002030895-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-η BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-18 | — | — | WO | disclosed |