Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 2/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.38 |
| ▸ | CCR9 | P51686 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6856145 | 0.89 | EDNRB (0.41) | EDNRBFABP4KDM4EALDH1A1MAPT | |
| SCHEMBL6858324 | 0.80 | KDM4E (0.43) | EDNRBFABP4KDM4EALDH1A1MAPT | |
| SCHEMBL6857652 | 0.73 | SERPINE1 (0.57) | EDNRBMAPTSERPINE1EDNRAPOLB | |
| SCHEMBL6856142 | 0.72 | KDM4E (0.42) | EDNRBFABP4KDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL6859387 | 0.70 | SERPINE1 (0.57) | EDNRBSERPINE1EDNRAMAPK8 | |
| SCHEMBL6856151 | 0.69 | SERPINE1 (0.50) | EDNRBSERPINE1CCR9EDNRA | |
| SCHEMBL27597871 | 0.69 | SERPINE1 (0.49) | EDNRBSERPINE1CCR9EDNRA | |
| SCHEMBL6851399 | 0.67 | SERPINE1 (0.49) | MAPTSERPINE1CACNA1GMAPK8POLB | |
| SCHEMBL6859339 | 0.67 | YWHAH (0.47) | EDNRBEDNRAPOLB | |
| SCHEMBL6858283 | 0.66 | MAPK8 (0.45) | EDNRBSERPINE1EDNRACACNA1GMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6787651-B2 | 2-CARBOXY-SUBSTITUTED; TREATING OSTEOPENIA, OSTEOPOROSIS, CANCER, DIABETES AND ATHEROSCLEROSIS. | SMITHKLINE BEECHAM CORPORATION | 2004-09-07 | — | — | US | disclosed |
| EP-1341761-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-$g(g) BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002030895-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-η BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-18 | — | — | WO | disclosed |