YWHAH — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL29068286	1.00	6/20
SCHEMBL30490432	1.00	6/20
SCHEMBL30490434	0.90	6/20
SCHEMBL30490436	0.70	6/20
SCHEMBL30490429	1.00	5/20
SCHEMBL30490431	0.80	5/20
SCHEMBL30490428	0.79	5/20
SCHEMBL22346544	0.50	5/20
SCHEMBL30490435	0.65	4/20
SCHEMBL4260289	0.53	4/20
SCHEMBL30490433	0.51	4/20
SCHEMBL4261606	0.47	4/20
SCHEMBL8167666	0.46	4/20
SCHEMBL4257381	0.42	4/20
SCHEMBL23641029	0.44	3/20
SCHEMBL8171636	0.41	3/20
SCHEMBL2555312	0.54	2/20
SCHEMBL4885587	0.53	2/20
SCHEMBL4266132	0.49	2/20
SCHEMBL12665133	0.48	2/20

Clinical trials — most relevant to YWHAH by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study	PHASE4	COMPLETED
Reducing the Risk of Drug-Induced QT Interval Lengthening in Women	PHASE4	COMPLETED
Safety and Impact of Dasatinib on Viral Persistence and Inflammation in People With HIV Under Antiretroviral Treatment	PHASE2	COMPLETED
Lapatinib Ditosylate in Treating Patients With Unresectable Liver or Biliary Tract Cancer	PHASE2	COMPLETED
SCARFREE-001: Verteporfin for Scar Prevention	PHASE2	NOT_YET_RECRUITING
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Auranofin in Treating Patients With Recurrent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer	EARLY_PHASE1	COMPLETED
Relationship of YWHAH Polymorphisms to Rheumatoid Arthritis Disease Severity	nan	COMPLETED
IVM for Patients With Low Ovarian Response. Does it Improve IVFoutcomes and Does it Improve the Following IVF Cycle?	nan	UNKNOWN
Semen Analysis Changes in Covid-19 Positivepatients	nan	COMPLETED
Studying Protein Expression in Tissue Samples From Younger Patients With Rhabdomyosarcoma	nan	COMPLETED
Blood-based Biomarkers for the Prognosis of Sports Related Concussion	nan	COMPLETED
Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome	nan	ACTIVE_NOT_RECRUITING
X-chromosome Inactivation, Epigenetics and the Transcriptome	nan	COMPLETED
Family Blood Pressure Program - GenNet Network	nan	COMPLETED
Cell Membrane Potential Regulates Spatial-Specific Mechanoptosis Resistance and Metastasis in Colorectal Cancer Via Mechanotransduction and the PVR/CD96 Axis	nan	COMPLETED
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients	nan	COMPLETED
Identification of an Asthma Susceptibility Gene on 3P	nan	COMPLETED
The Synergistic Effects of AIH and FES in Persons With MS	nan	ACTIVE_NOT_RECRUITING
Heart Failure and a Preserved Ejection Fraction	nan	COMPLETED
Family Blood Pressure Program - HyperGEN	nan	COMPLETED
Immune Cell Response to Stimuli	nan	RECRUITING
Family Blood Pressure Program - SAPPHIRe Network	nan	COMPLETED
Family Blood Pressure Program - GENOA	nan	COMPLETED
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact	nan	UNKNOWN
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Cardiopulmonary and Right Ventricular Function in Health and Disease	nan	UNKNOWN
Amplification of Zinc Finger Protein 217 Gene in Multiple Myeloma	nan	UNKNOWN
Genomic Predictors of Recurrent Pregnancy Loss	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a YWHAH binder may also engage these)

Protein	Name	Similarity
P68509	—	1.000	P68509 →
YWHAG	14-3-3 protein gamma	1.000	landscape →
Q5RC20	—	1.000	Q5RC20 →
Q5ZLQ6	—	1.000	Q5ZLQ6 →
Q6PCG0	—	1.000	Q6PCG0 →
Q6PC29	—	1.000	Q6PC29 →
Q6UFZ3	—	1.000	Q6UFZ3 →
P35213	—	1.000	P35213 →
P68511	—	1.000	P68511 →
P68250	—	1.000	P68250 →
P61982	—	1.000	P61982 →
Q6UFZ8	—	1.000	Q6UFZ8 →
P68252	—	1.000	P68252 →
Q7T356	—	1.000	Q7T356 →
Q6UFZ9	—	1.000	Q6UFZ9 →
P48347	—	0.999	P48347 →
Q6NRY9	—	0.999	Q6NRY9 →
YWHAZ	14-3-3 protein zeta/delta	0.999	landscape →
Q5R651	—	0.999	Q5R651 →
YWHAQ	14-3-3 protein theta	0.999	landscape →
Q4R572	—	0.999	Q4R572 →
YWHAB	14-3-3 protein beta/alpha	0.999	landscape →
P68255	—	0.999	P68255 →
Q52M98	—	0.999	Q52M98 →
A4K2U9	—	0.999	A4K2U9 →
Q91896	—	0.999	Q91896 →
P42649	—	0.999	P42649 →
P68510	—	0.999	P68510 →
Q1HR36	—	0.999	Q1HR36 →
Q9CQV8	—	0.999	Q9CQV8 →