Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 20/20 | 0.46 |
| ▸ | CX3CR1 | P49238 | 2/20 | 0.42 |
| ▸ | CCR7 | P32248 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6866731 | 0.86 | CXCR2 (0.52) | CXCR2CX3CR1CHRM5 | |
| SCHEMBL6868308 | 0.80 | CXCR2 (0.51) | CXCR2CX3CR1CHRM5 | |
| SCHEMBL6997947 | 0.79 | CXCR2 (0.56) | CXCR2CX3CR1CHRM5 | |
| SCHEMBL6866063 | 0.78 | CXCR2 (0.52) | CXCR2CX3CR1 | |
| SCHEMBL842857 | 0.78 | CXCR2 (0.66) | CXCR2CX3CR1CCR7 | |
| SCHEMBL842322 | 0.78 | CXCR2 (0.70) | CXCR2CX3CR1CHRM5 | |
| SCHEMBL6866478 | 0.78 | KMT2A (0.44) | CXCR2 | |
| SCHEMBL6863816 | 0.76 | CXCR2 (0.42) | CXCR2 | |
| SCHEMBL6865116 | 0.72 | CXCR2 (0.53) | CXCR2CX3CR1CHRM5 | |
| SCHEMBL6868967 | 0.71 | CXCR2 (0.69) | CXCR2CX3CR1CCR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | claimed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | claimed |
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | disclosed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |