Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 19/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997947 | 0.82 | CXCR2 (0.56) | CXCR2CHRM5CX3CR1KDM4EMEN1 | |
| SCHEMBL842322 | 0.81 | CXCR2 (0.70) | CXCR2CHRM5CX3CR1 | |
| SCHEMBL6866063 | 0.78 | CXCR2 (0.52) | CXCR2CX3CR1 | |
| SCHEMBL6866731 | 0.78 | CXCR2 (0.52) | CXCR2CHRM5CX3CR1 | |
| SCHEMBL4373932 | 0.74 | CXCR2 (0.54) | CXCR2CHRM5CX3CR1 | |
| SCHEMBL6868308 | 0.72 | CXCR2 (0.51) | CXCR2CHRM5CX3CR1 | |
| SCHEMBL6859563 | 0.72 | CXCR2 (0.46) | CXCR2CHRM5CX3CR1 | |
| SCHEMBL6865123 | 0.72 | CXCR2 (0.56) | CXCR2MEN1ALDH1A1KMT2A | |
| SCHEMBL4236680 | 0.71 | CXCR2 (0.57) | CXCR2CX3CR1KDM4EMEN1ALDH1A1 | |
| SCHEMBL6863822 | 0.70 | CXCR2 (0.56) | CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | claimed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | claimed |
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | disclosed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| EP-1104425-A1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009511-A1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-02-24 | — | — | WO | disclosed |