Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 12/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.58 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6859506 | 0.90 | ADORA2A (0.62) | ADORA2AADORA1PIK3R1PIK3CANPC1 | |
| SCHEMBL6859543 | 0.88 | ADORA2A (0.64) | ADORA2AADORA1NPC1ALDH1A1RAB9A | |
| SCHEMBL6859739 | 0.87 | ADORA2A (0.59) | ADORA2AADORA1PIK3R1PIK3CAADORA2B | |
| SCHEMBL6859687 | 0.86 | ADORA2A (0.58) | ADORA2AADORA1PIK3R1PIK3CANPC1 | |
| SCHEMBL6852934 | 0.82 | ADORA2A (0.56) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6858307 | 0.82 | ADORA2A (0.56) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6859714 | 0.79 | ADORA2A (0.53) | ADORA2AADORA1ALDH1A1ADORA2B | |
| SCHEMBL6858208 | 0.79 | ADORA2A (0.58) | ADORA2AADORA1SMN1; SMN2ADORA2B | |
| SCHEMBL6858206 | 0.79 | ADORA2A (0.58) | ADORA2AADORA1SMN1; SMN2ADORA2B | |
| SCHEMBL6852762 | 0.78 | ADORA2A (0.59) | ADORA2AADORA1HPGDADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6787541-B1 | MOVEMENT DISORDERS, PARKINSON'S DISEASE | VERNALIS RESEARCH LIMITED (GB) | 2004-09-07 | — | — | US | disclosed |