Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.39 |
| ▸ | AHCY | P23526 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL654274 | 0.92 | NR1D1 (0.63) | NR1D1MEN1KMT2AGPR119JAK2 | |
| SCHEMBL655030 | 0.86 | NR1D1 (0.55) | NR1D1MEN1KMT2AGPR119JAK2 | |
| SCHEMBL655062 | 0.84 | MBTPS1 (0.49) | MBTPS1SSTR4SLC6A2SLC6A4CYP2D6 | |
| SCHEMBL652795 | 0.83 | NR1D1 (0.61) | NR1D1MEN1KMT2AGPR119JAK2 | |
| SCHEMBL654162 | 0.83 | NR1D1 (0.65) | NR1D1MEN1KMT2AGPR119JAK2 | |
| SCHEMBL654296 | 0.82 | NR1D1 (0.64) | NR1D1MEN1KMT2AGPR119JAK2 | |
| SCHEMBL655286 | 0.81 | NR1D1 (0.60) | NR1D1MEN1KMT2AGPR119JAK2 | |
| SCHEMBL655013 | 0.79 | NR1D1 (0.65) | NR1D1MEN1KMT2AGPR119JAK2 | |
| SCHEMBL653150 | 0.78 | SLC6A2 (0.45) | NR1D1MBTPS1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL653650 | 0.78 | NR1D1 (0.64) | NR1D1MEN1KMT2AGPR119JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448566-A2 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003045942-A2 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-06-05 | — | — | WO | disclosed |