Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 3/20 | 0.52 |
| ▸ | GSK3B | P49841 | 3/20 | 0.51 |
| ▸ | GCGR | P47871 | 4/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.48 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL67704 | 0.80 | MAPK13 (0.64) | RAF1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL6466096 | 0.80 | RAF1 (0.68) | RAF1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL4487525 | 0.79 | GSK3B (0.73) | GSK3BGSK3A | |
| SCHEMBL67380 | 0.77 | MAPK13 (0.65) | RAF1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL4551617 | 0.74 | KDM4E (0.67) | RAF1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL65858 | 0.73 | MAPK13 (0.64) | RAF1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL5759498 | 0.73 | MAPK14 (0.61) | RAF1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL12462140 | 0.73 | MAPK14 (0.62) | RAF1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL14689935 | 0.73 | RAF1 (0.67) | RAF1ALOX5MAPK14MAPK13MAPK12 | |
| SCHEMBL12461160 | 0.72 | RAF1 (0.62) | RAF1ALOX5MAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865732-B2 | Heterocyclic compounds and uses thereof | NOVARTIS AG (CH) | 2014-10-21 | — | — | US | disclosed |
| US-8865732-B2 | Heterocyclic compounds and uses thereof | NOVARTIS AG (CH) | 2014-10-21 | — | — | US | disclosed |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | NOVARTIS AG (CH) | 2013-08-15 | — | — | US | disclosed |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | NOVARTIS AG (CH) | 2013-08-15 | — | — | US | disclosed |
| US-8129394-B2 | Heteroaryl-substituted imidazole compounds and uses thereof | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-8129394-B2 | Heteroaryl-substituted imidazole compounds and uses thereof | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-8129394-B2 | Heteroaryl-substituted imidazole compounds and uses thereof | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | NOVARTIS AG (CH) | 2010-01-07 | — | — | US | disclosed |
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | NOVARTIS AG (CH) | 2010-01-07 | — | — | US | disclosed |
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | NOVARTIS AG (CH) | 2010-01-07 | — | — | US | disclosed |
| WO-2009115572-A2 | NOVEL HETEROCYCLIC COMPOUNDS AND USES THEROF | NOVARTIS AG (CH) | 2009-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | BRAF, ARAF, KRAS | RAF1 4/4885ALOX5 4390/4885MAPK14 484/4885 |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | BRAF, RAF1, HRAS | RAF1 2/4885ALOX5 3656/4885MAPK14 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.