Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 5/20 | 0.38 |
| ▸ | APP | P05067 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6859891 | 0.94 | KMT2A (0.40) | KMT2AMEN1SSTR5ACHEAPP | |
| SCHEMBL6764725 | 0.91 | PDE10A (0.37) | ALDH1A1HSD17B10 | |
| SCHEMBL6760546 | 0.90 | PDE5A (0.41) | — | |
| Bicarbonate SCHEMBL6638242 | 0.90 | PDE5A (0.43) | KMT2AMEN1SSTR5ACHEAPP | |
| SCHEMBL6861041 | 0.89 | TRPV1 (0.40) | KMT2AMEN1SSTR5ACHEAPP | |
| SCHEMBL6859716 | 0.88 | ESR1 (0.41) | KMT2AMEN1ALDH1A1MAPTALOX15 | |
| SCHEMBL6764817 | 0.86 | PTPN12 (0.48) | KMT2AMEN1KDM4EALDH1A1POLB | |
| Beminafil SCHEMBL6236540 | 0.84 | PDE5A (0.41) | — | |
| Beminafil SCHEMBL2421274 | 0.83 | PDE5A (0.47) | — | |
| Beminafil SCHEMBL2421268 | 0.83 | PDE5A (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6787548-B1 | CARDIOVASCULAR INSUFFICIENCY AND ERECTILE DYSFUNCTION; 3-(4-(3-CHLORO-4-HYDROXYBENZYLAMINO) BENZO(4,5)THIENO(2,3-D)PYRIMIDIN-2-YL)PROPIONIC ACID | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2004-09-07 | — | — | US | disclosed |