Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5882851 | 0.72 | KMT2A (0.35) | MAPTTHRBALDH1A1KDM4EIDO1 | |
| SCHEMBL5882849 | 0.70 | IDO1 (0.36) | MAPTTHRBALDH1A1KDM4EIDO1 | |
| SCHEMBL5883143 | 0.59 | KMT2A (0.36) | MAPTALDH1A1IDO1L3MBTL1MEN1 | |
| SCHEMBL17008815 | 0.57 | MRGPRX4 (0.38) | MAPTALDH1A1KDM4EGAAPOLB | |
| SCHEMBL2723073 | 0.56 | AR (0.44) | ALDH1A1CYP3A4POLB | |
| SCHEMBL4981411 | 0.56 | GABRA1 (0.51) | ALDH1A1CYP3A4 | |
| SCHEMBL12670381 | 0.56 | CYP1A2 (0.50) | MAPTTHRBALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL1741193 | 0.54 | CYP2A6 (0.38) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL9447458 | 0.54 | GABRA1 (0.38) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL7042258 | 0.54 | CYP3A4 (0.44) | MAPTTHRBALDH1A1L3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149069-B1 | PHENYLGLYCINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2004-08-25 | — | — | EP | disclosed |
| EP-1149069-A1 | PHENYLGLYCINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-6242644-B1 | FOR TREATING THROMBOSIS, APOPLEXY, CARDIAC INFARCTION, INFLAMATION AND ARTHEROSCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-06-05 | — | — | US | disclosed |
| WO-2000035858-A1 | PHENYLGLYCINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |