SCHEMBL6862062

SCHEMBL6862062

CCCOc1cccc(-c2cc(=O)n(C)c3ccc(C(=O)c4ccc(Cl)cc4)cc23)c1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FNTA P49354 7/20 0.43
FNTB P49356 7/20 0.43
PPARG P37231 1/20 0.42
SMARCA2 P51531 1/20 0.42
SMARCA4 P51532 1/20 0.42
BRD9 Q9H8M2 1/20 0.42
NTRK1 P04629 1/20 0.40
KMT2A Q03164 1/20 0.40
CYP3A4 P08684 1/20 0.39
LMNA P02545 1/20 0.39
MAPK1 P28482 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
BACE1 P56817 1/20 0.39
MAPT P10636 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
HSD17B10 Q99714 2/20 0.38
ALDH1A1 P00352 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5509068 0.88 MAPT (0.46) FNTAFNTBCYP3A4MAPTRXFP1
SCHEMBL30419724 0.85 FNTA (0.56) FNTAFNTBKMT2ACYP3A4HSD17B10
SCHEMBL1538260 0.85 FNTA (0.56) FNTAFNTBKMT2ACYP3A4HSD17B10
SCHEMBL6870737 0.84 FNTA (0.50) FNTAFNTBSMARCA2SMARCA4BRD9
SCHEMBL6871215 0.83 FNTA (0.51) FNTAFNTBSMARCA2SMARCA4BRD9
SCHEMBL6866186 0.83 FNTA (0.47) FNTAFNTBCYP3A4MAPK1HSD17B10
SCHEMBL5516658 0.82 HSD17B10 (0.57) FNTAFNTBCYP3A4LMNAMAPT
SCHEMBL5722628 0.82 FNTA (0.46) FNTAFNTBCYP3A4LMNAMAPT
SCHEMBL1644048 0.82 FNTA (0.48) FNTAFNTBCYP3A4LMNAMAPT
SCHEMBL13573663 0.80 FNTA (0.47) FNTAFNTBCYP3A4HSD17B10ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1106610-B1 Farnesyl transferase inhibiting 2-quinolone derivatives JANSSEN PHARMACEUTICA NV (BE) 2004-06-16 EP disclosed
EP-1019395-B1 FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES JANSSEN PHARMACEUTICA NV (BE) 2002-01-30 EP disclosed
EP-1106610-A1 Farnesyl transferase inhibiting 2-quinolone derivatives Janssen Pharmaceutica N.V. (BE) 2001-06-13 EP disclosed
EP-1019395-A1 FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2000-07-19 EP disclosed
US-5968952-A ANTITUMOR AGENTS JANSSEN PHARMACEUTICA, N.V. (BE) 1999-10-19 US disclosed
WO-1997016443-A1 FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1997-05-09 WO disclosed