Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 7/20 | 0.47 |
| ▸ | FNTB | P49356 | 7/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30419724 | 0.91 | FNTA (0.56) | FNTAFNTBHSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL1538260 | 0.91 | FNTA (0.56) | FNTAFNTBHSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL5516658 | 0.89 | HSD17B10 (0.57) | FNTAFNTBHSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL5722628 | 0.88 | FNTA (0.46) | FNTAFNTBHSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL1644048 | 0.88 | FNTA (0.48) | FNTAFNTBHSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL5509068 | 0.86 | MAPT (0.46) | FNTAFNTBHSD17B10CYP3A4 | |
| SCHEMBL13573663 | 0.86 | FNTA (0.47) | FNTAFNTBHSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL6162274 | 0.85 | FNTA (0.44) | FNTAFNTBHSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL5657960 | 0.83 | FNTA (0.48) | FNTAFNTBHSD17B10ALDH1A1GLA | |
| SCHEMBL6862062 | 0.83 | FNTA (0.43) | FNTAFNTBHSD17B10CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1106610-B1 | Farnesyl transferase inhibiting 2-quinolone derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2004-06-16 | — | — | EP | disclosed |
| EP-1019395-B1 | FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2002-01-30 | — | — | EP | disclosed |
| EP-1106610-A1 | Farnesyl transferase inhibiting 2-quinolone derivatives | Janssen Pharmaceutica N.V. (BE) | 2001-06-13 | — | — | EP | disclosed |
| EP-1019395-A1 | FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-07-19 | — | — | EP | disclosed |
| US-5968952-A | ANTITUMOR AGENTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1999-10-19 | — | — | US | disclosed |
| WO-1997016443-A1 | FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-05-09 | — | — | WO | disclosed |