Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 15/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 15/20 | 0.56 |
| ▸ | RXRA | P19793 | 2/20 | 0.48 |
| ▸ | RXRB | P28702 | 2/20 | 0.48 |
| ▸ | RXRG | P48443 | 2/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1138814 | 0.95 | KEAP1 (0.56) | KEAP1NFE2L2 | |
| SCHEMBL1139961 | 0.90 | KEAP1 (0.51) | KEAP1NFE2L2 | |
| SCHEMBL6861327 | 0.88 | KEAP1 (0.56) | KEAP1NFE2L2RXRARXRBRXRG | |
| SCHEMBL1140188 | 0.88 | KEAP1 (0.71) | KEAP1NFE2L2RXRARXRBRXRG | |
| SCHEMBL1138908 | 0.87 | KEAP1 (0.54) | KEAP1NFE2L2 | |
| SCHEMBL6864191 | 0.87 | KEAP1 (0.54) | KEAP1NFE2L2RXRARXRBRXRG | |
| SCHEMBL6864126 | 0.87 | KEAP1 (0.59) | KEAP1NFE2L2RXRARXRBRXRG | |
| SCHEMBL6855976 | 0.87 | KEAP1 (0.59) | KEAP1NFE2L2RXRARXRBRXRG | |
| SCHEMBL6861350 | 0.86 | KEAP1 (0.58) | KEAP1NFE2L2RXRARXRBRXRG | |
| SCHEMBL6855155 | 0.85 | KEAP1 (0.56) | KEAP1NFE2L2RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6790866-B2 | SUCH AS 4-(2-PHENYLSULFONYLAMINO-5-CHLOROBENZOYLAMINO)BENZOIC ACID FOR USE AS PROSTAGLANDIN E2 ANTAGONIST OR AGONIST; FOR INHIBITION OF UTERINE CONTRACTION, ANALGESICS, ANTIDIARRHEALS, SLEEP INDUCERS, AND/OR FOR INCREASE OF VESICAL CAPACITY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-09-14 | — | — | US | disclosed |