Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 9/20 | 0.43 |
| ▸ | ESR1 | P03372 | 9/20 | 0.43 |
| ▸ | PRNP | P04156 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6861853 | 0.84 | ESR2 (0.56) | ESR2ESR1PRNPMETAP1 | |
| SCHEMBL6862469 | 0.81 | ESR2 (0.55) | ESR2ESR1PRNP | |
| SCHEMBL6860520 | 0.77 | ESR2 (0.50) | ESR2ESR1PRNP | |
| SCHEMBL14339932 | 0.76 | ESR2 (0.71) | ESR2ESR1 | |
| SCHEMBL2419980 | 0.75 | ESR2 (0.60) | ESR2ESR1PRNP | |
| SCHEMBL2418485 | 0.75 | ESR2 (0.57) | ESR2ESR1PRNP | |
| SCHEMBL2418445 | 0.74 | ESR2 (0.72) | ESR2ESR1 | |
| SCHEMBL6860603 | 0.74 | METAP1 (0.47) | PRNPMETAP1CA1CA2CA4 | |
| SCHEMBL14524720 | 0.74 | ESR2 (0.73) | ESR2ESR1 | |
| SCHEMBL2417755 | 0.72 | ESR2 (0.53) | ESR2ESR1PRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6800785-B1 | ALKYLATING INDANONE TO YIELD INTERMEDIATE, ADDING NUCLEOPHILE TO YIELD DIENE, CYCLIZING DIENE VIA RING CLOSING OLEFIN METATHESIS REACTION TO YIELD ALLYLIC ALCOHOL, REARRANGING VIA ALLYLIC OXIDATIVE REARRANGEMENT TO YIELD ENE ONE, DEPROTECTING | MERCK & CO., INC. | 2004-10-05 | — | — | US | disclosed |