SCHEMBL6862976

SCHEMBL6862976

CNC(=O)c1ccncc1-c1ccccc1C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 2/20 0.47
L3MBTL1 Q9Y468 2/20 0.44
KMT2A Q03164 1/20 0.44
MAPK1 P28482 1/20 0.44
CYP1A2 P05177 2/20 0.44
CYP3A4 P08684 2/20 0.44
CYP2D6 P10635 1/20 0.44
TYK2 P29597 1/20 0.44
GPBAR1 Q8TDU6 6/20 0.43
CYP17A1 P05093 1/20 0.42
FNTA P49354 1/20 0.41
FNTB P49356 1/20 0.41
KDM4C Q9H3R0 1/20 0.41
ALDH1A1 P00352 1/20 0.40
LMNA P02545 1/20 0.40
CYP2C9 P11712 1/20 0.40
ALOX15 P16050 1/20 0.40
TSHR P16473 1/20 0.40
HSD17B10 Q99714 1/20 0.40
MKNK1 Q9BUB5 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6882249 0.88 MAPK1 (0.48) TACR1L3MBTL1KMT2AMAPK1TYK2
SCHEMBL6870086 0.83 MYC (0.53) TACR1L3MBTL1KMT2AGPBAR1KDM4C
SCHEMBL29971293 0.82 GAA (0.53) L3MBTL1KMT2AMAPK1CYP3A4ALDH1A1
SCHEMBL21056662 0.82 KDM4E (0.54) TACR1L3MBTL1KMT2AGPBAR1ALDH1A1
SCHEMBL27821329 0.81 SIRT3 (0.57) TACR1GPBAR1MKNK1MKNK2
SCHEMBL30674829 0.79 KDM4C (0.49) L3MBTL1KMT2AMAPK1CYP1A2CYP3A4
SCHEMBL6868605 0.76 TACR1 (0.67) TACR1MAPK1GPBAR1
SCHEMBL30107188 0.75 SIRT3 (0.61) L3MBTL1MAPK1CYP1A2CYP3A4TYK2
SCHEMBL13162016 0.75 SIRT3 (0.61) L3MBTL1MAPK1CYP1A2CYP3A4TYK2
SCHEMBL30070596 0.75 HTT (0.62) KMT2AMAPK1CYP1A2CYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1157005-B1 3-PHENYLPYRIDINE DERIVATIVES AND THEIR USE AS NK-1 RECEPTOR ANTAGONISTS HOFFMANN LA ROCHE (CH) 2004-10-20 EP disclosed
EP-1157005-A1 3-PHENYLPYRIDINE DERIVATIVES AND THEIR USE AS NK-1 RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2001-11-28 EP disclosed
US-6225316-B1 GOOD AFFINITY TO THE NK-1 RECEPTOR. HOFFMANN-LA ROCHE INC. 2001-05-01 US disclosed
WO-2000050401-A1 3-PHENYLPYRIDINE DERIVATIVES AND THEIR USE AS NK-1 RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2000-08-31 WO disclosed