Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.60 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27894364 | 0.86 | MKNK1 (0.56) | HTTKMT2AMKNK1MKNK2CYP1A2 | |
| SCHEMBL974618 | 0.85 | KMT2A (0.59) | HTTKMT2AMKNK1MKNK2ALDH1A1 | |
| SCHEMBL4379502 | 0.83 | KMT2A (0.54) | HTTKMT2AMKNK1MKNK2ALDH1A1 | |
| SCHEMBL3223294 | 0.83 | CHRNB2 (0.65) | HTTKMT2AALDH1A1CHRNB2CHRNB4 | |
| SCHEMBL9206961 | 0.81 | CYP2A6 (0.53) | HTTKMT2AMKNK1MKNK2CYP1A2 | |
| SCHEMBL10968862 | 0.81 | HTT (0.54) | HTTKMT2AMKNK1MKNK2CYP1A2 | |
| SCHEMBL29644805 | 0.81 | KMT2A (0.61) | HTTKMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL30118927 | 0.81 | KMT2A (0.61) | HTTKMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL13435236 | 0.81 | KMT2A (0.61) | HTTKMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL27655231 | 0.80 | KMT2A (0.48) | HTTKMT2AMKNK1MKNK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115819417-A | Pyrazolopyridine derivatives as HPK1 modulators and their use for the treatment of cancer | 因赛特公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-109923114-B | Pyrazolopyridine derivatives as HPK1 modulators and their use for the treatment of cancer | 因赛特公司 | 2022-11-01 | — | — | CN | disclosed |